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Old 08-19-2009, 02:34 PM
matoozie's Avatar
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Post Muscadine 101 - Beyond Resveratrol

Everyone has heard about resveratrol and what it does, but what is so great about muscadine?
Muscadine grapes are the largest grapes in nature, and are native to the southeastern US.
Amazing size, isn't it? They can be as big as plums.

Something else that is special about muscadine grapes is that they are the only grape in nature with an extra chromosone. They have 20, instead of the average 19. This allows for the creation of special combination phytonutrients that aren't found in other grapes.

Muscadines are naturally high in polyphenols. Polyphenols are a family of substances with wonderful health properties, and resveratrol is just one of them. The skins are seeds are especially rich in these substances... the juice doesn't have nearly as much. And different varieties of muscadine have different levels of polyphenols.

Muscadine is rich in a polyphenol called ellagic acid. It also has derivatives of ellagic acid that were never before identified. Must be that extra chromosome.
Identification of ellagic acid conjugates and othe...[J Agric Food Chem. 2005] - PubMed Result

Ellagic acid has over 900 studies about it.

Here are some results of some of the more fantabulous studies on ellagic acid:

* Anti-inflammatory, anti-coagulatory, alleviated weight loss, lowered triglycerided, etc.
Anti-inflammatory and anti-coagulatory activities ...[Nutr Metab (Lond). 2009] - PubMed Result

* Possible positive effect against breast cancer
Effect of ellagic acid on the expression of human ...[Clin Biochem. 2009] - PubMed Result

* (Begins by noting ellagic acid has anti-oxidant, anti-carcinogenic and anti-mutagenic effects.)
* Possible theraputic agent for allergic diseases
Ellagic Acid attenuates immunoglobulin E-mediated ...[Biol Pharm Bull. 2009] - PubMed Result

* Stimulated die off of pancreatic cancer cells
Ellagic acid induces apoptosis through inhibition ...[World J Gastroenterol. 2008] - PubMed Result

You get the point...

Let's look at muscadine. It has all the good stuff above and more. It was learned that the purple and bronze varieties had the highest concentrations of polyphenols, and so they are the most desireable to use.

Let's see what kinds of studies are available on muscadine...

* Muscadine has one of the highest antioxidant levels of any fruit.
* Muscadine shows significant anti-inflammatory properties (50% decrease in this study)
I can vouch for this. With a back injury this time last year I was doing quite well. Recently I went off of our muscadine product for nearly 2 months and pain began to return. I saw a significant improvement in just days of getting back onto the product. Pain reduction back to virtually pain-free, stiffness greatly reduced.
Antiinflammatory properties of the muscadine grape...[J Agric Food Chem. 2005] - PubMed Result

* Polyphenols from muscadines may have anti-cancer properties.
Study of anticancer activities of muscadine grape ...[J Agric Food Chem. 2005] - PubMed Result

* Anticancer properties from ellagic acid rich muscadine extracts
Induction of cell death in Caco-2 human colon carc...[J Agric Food Chem. 2006] - PubMed Result

* Muscadine extract and resveratrol inhibit prostate cancer growth
Inhibition of prostate cancer growth by muscadine ...[Cancer Res. 2007] - PubMed Result

* Muscadine skin/seed extracts exhibit significant topical anti-inflammatory properties
Topical anti-inflammatory activities of Vitis rotu...[J Med Food. 2007] - PubMed Result

* Muscadine skin/seed extracts inhibit AGE protein formation (glycation)
* Muscadine skin/seed extracts may benefit people with progression of diabetic complications
Inhibition of protein glycation by skins and seeds...[Biofactors. 2007] - PubMed Result

* Muscadine seed extract exhibits antimicrobial effects on E. coli
Antimicrobial effect of water-soluble muscadine se...[J Food Prot. 2008] - PubMed Result

* Muscadine skin extract most antibacterial effect on H. pylori (ulcer bacteria) of all grape skin extracts tested
(One lady who used the muscadine extract, had suffered from acid reflux for over 30 years and found she no longer needed medication after less than a week. I wonder if she had this bacteria...)
Antibacterial effects of grape extracts on Helicob...[Appl Environ Microbiol. 2009] - PubMed Result

So in summary, studies are showing that these ingredients appear to have the following attributes:

* Anti-inflammatory
* Antimicrobial
* Anticancer
* Antioxidant
* Anti-mutagenic
And other stuff

So don't underestimate the power of a little grape...
Well... not so little
Susan Kramer
Awesome Nutrition for Real People
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